The potential of undenatured type II collagen against arthritis: a review
The global aging population has heightened the prevalence of bone and joint diseases, challenging patient quality of life and healthcare systems. Type II collagen, crucial for joint function, has garnered attention for its therapeutic potential. This article reviews undenatured type II collagen (UC-II), exploring its structure, extraction methods, and its role in arthritis treatment. It highlights UC-II's promising effects on alleviating joint inflammation and pain in osteoarthritis (OA) and rheumatoid arthritis (RA) through oral tolerance mechanisms. UC-II offers a well-tolerated, effective treatment with high patient acceptance and minimal side effects, making it a viable option for managing joint diseases.
Recent advances of collagen composite biomaterials for biomedical engineering: antibacterial functionalization and 3D-printed architecturalization
In biomedical engineering, collagen from natural sources has high biocompatibility and can be combined with various active ingredients to create multifunctional biomedical composite materials. However, medical-related infection issues and the precise treatment needs of patients require collagen composite biomaterials to have antibacterial properties and customized structures. This review explores the latest developments in the antibacterial functionalization of collagen composite materials, which expands the application of various antibacterial active ingredients in collagen medical materials. The architecturalization of collagen composite materials with 3D printing is explored to create structurally adjustable tissue engineering scaffolds, providing guidance for personalized customization of multifunctional materials to meet the specific needs of patients in the future.